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One commenter indicated that ensuring that MRFs are available, timely, and accurate is the foundation upon which innovators can build tools that actually help patients navigate the cost of healthcare, but the commenter expressed that the data in the MRFs are insufficient on their own to fully support a patient's understanding of their individual price, and offered the view that final rules governing MRF creation must work in tandem with the NSA policy

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Although it is not possible to draw direct comparisons from the real-world evidence study and the RCTs, these examples demonstrate how reporting the treatment effect from different perspectives can provide a broader understanding of the weight loss that can be expected with a medication, and can be useful for clinicians when assessing pharmacotherapeutic options for their patients