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This high longevity, along with their low metabolic rates, slow growth, and low recruitment rates, makes them particularly vulnerable and slow to recover from anthropogenic impacts (Risk et al., 2002

However, adverse effects are rare when used at the recommended dosage

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Human Equivalent Dose Calculations Using standard conversion formulas accounting for body surface area differences between species, a rat oral dose of 0.0045 mg/lb translates to approximately 0.00073 mg/lb in humans, yielding roughly 0.112 mg/day for a 154-pound person

This recomposition is the GH effect at work: it selectively preserves lean mass while mobilizing fat