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doi: 10.1155/2012/302537 107 AdemoluEOzbeyNErbilYTanrikuluSBarbarosUYanikBTet al

Genetic studies in mice have shown that reduced mitochondrial function in adipocytes has a causative role in systemic insulin resistance 20,21

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This restriction in ATP synthesis leads to ROS accumulation and oxidative stress, which in turn inhibits T cell self-renewal and contributes to T cell exhaustion