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By virtue of the absence of an Fc glycan, AMG 966 is a stable effector functionless (SEFL) antibody, which lacks the ability to interact with Fc receptors (11)

It is involved in making DNA, necessary in the production of new healthy cells

Briefly, Human GrK and its catalytically inactive mutant GrKSA, in which a serine has been replaced with Ala, were produced in Pichia pastoris and purified using cation-exchange chromatography