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The spatial arrangement of hepatocytes along the flow from the portal tract of the central vein ensures that bilirubin metabolism further emphasizes the intercellular transfer of bilirubin and its metabolites, maintaining overall homeostasis [28]

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In particular, the proteins complement component 4 and apolipoprotein E displayed abnormal expression at week 12 before the clinical diagnosis of PE, suggesting their value as clinical biomarkers (239)

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Phototoxic reactions are characterised by a rapid onset , typically developing within minutes to a few hours following sun exposure