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Intraneuronal amyloid oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

Oxidative stress occurs when reactive molecules build up faster than the body can comfortably neutralize them

91 The maladjustment of methionine and SAM metabolism has been well-accepted in ALD, while the effect of this maladjustment on downstream products has not been fully investigated

It is commonly believed that hypothyroidism is a chronic condition without a definitive cure, necessitating a lifetime of management through thyroid medication such as levothyroxine