alcohol acetominophen glutathione napqi cytochrome p450

alcohol acetominophen glutathione napqi cytochrome p450 Acetaminophen toxicity Flashcards | Quizlet

Name: alcohol acetominophen glutathione napqi cytochrome p450 Acetaminophen toxicity Flashcards | Quizlet
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Acetaminophen toxicity Flashcards Quizlet GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Translational biomarkers of acetaminophen induced acute liver injury Archives of Toxicology Springer Nature Link Xia & He Publishing What happens when you take paracetamol? Your liver gets to work breaking it down into harmless bits. But here's the twist Those bits need a taxi (yep, a molecule called glutathione)

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J Psychiatry Neurosci 46(1):E166-e175 Grant RS, Coggan SE, Smythe GA (2009) The physiological action of picolinic acid in the human brain

MALDI-QIT-TOF-MS analysis showed that in unstimulated RAW264.7 cells, there were four phosphorylated residues including Tyr3, Tyr7, Ser42, and Tyr198 in GSTP, whereas five phosphorylated amino acids including Tyr3, Tyr7, Ser42, Tyr198, and Ser184 in GSTP could be observed in LPS-stimulated cells (Figure 5A)

Gastroenterology 2001, 121: 1473-1484

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