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Sexual dimorphism of osteoclast reliance on mitochondrial oxidation of energy substrates in the mouse

We found that the unbalanced relationship between Nrf2 and NF-B may induce or aggravate toxic responses, while substances that regulate the relationship between Nrf2 and NF-B may play a protective role-restoring Nrf2 activity, thereby enhancing antioxidant capacity and reducing NF-B-mediated inflammatory responses

In particular, bavachin has proven effective in inhibiting the growth of MG63 and HOS osteosarcoma cell lines

Lai Q, Liu FM, Rao WL, et al

Radiotherapy is a fantastic alternative for people in whom excision may not be possible (medically or technically inoperable) or may be viewed as less optimal (e.g., cosmetic outcome)