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[78] Cellular respiration abnormalities in cellular respiration including a reduction in glycolysis, [79] including impaired pyruvate dehydrogenase [80] increased lactic acid [81] [82] [83] [84] [4] reduction in metabolites reflecting a slowed metabolism [85] analysis of peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction, supporting a model...that would suggest an elevation of oxidative stress

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Nat Rev Neurosci 16:305 OBrien WT, Huang J, Buccafusca R et al (2011) Glycogen synthase kinase-3 is essential for -arrestin-2 complex formation and lithium-sensitive behaviors in mice

Hence there were two main goals of this study