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Memisogullari R et al reported that glutathione peroxidase activity was significantly decreased in type II diabetes mellitus

Cel Sci 127, 36493658

This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)

doi: 10.1002/eji.200324833 52 ElliottD

Consistently, low-dose intranasal administration of RNs has been investigated for neuroprotection in an EAE mouse model of MS