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However, serious side effects such as allergic reactions or heart failure in individuals with heart disease are rare but possible

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demonstrated in Drosophila embryo healing that mitochondrially-derived H 2 O 2 produced downstream of intracellular Ca 2+ bursts led to the polarisation of the actomyosin cytoskeleton and E-cadherin distribution around the wound to promote wound healing 117

Here, we highlighted the studies that analyze strategies to delay or prevent the progression of these diseases using TRP modulation, with some encouraging results, as well as highlighting unanswered questions yet to be studied

Weight gain, particularly around the abdomen, is another common concern