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Damaged cells further stimulate microglial activation, which also contributes to free radical production [141]

Attenuation of plasma annexin A1 in human obesity

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100 The activation of PPAR leads to the maintenance of glucose/lipid uptake and storage, M2 polarization, fatty acid oxidation, and insulin secretion, which in turn, ultimately results in the improvement of insulin sensitivity

2.3 Primary detection methods of TMAO The detection of TMAO can be achieved through various methods, including enzyme-linked immunosorbent assay (ELISA), Liquid chromatography-mass spectrometry (LC-MS/MS), Nuclear magnetic resonance spectroscopy (NMR), gas chromatography, and electrochemical sensors