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Common symptoms include: Sharp or stabbing pain in the lower chest or upper abdomen A clicking, popping, or slipping sensation in the ribs Pain that worsens with twisting, bending, deep breathing, coughing, or sneezing Intermittent episodes rather than constant pain Pain that radiates to the back or flank Tenderness along the lower rib margin Many patients describe a persistent feeling that a rib is popping out of place

Lets shift gears and look at the genetic variants that can increase the odds of T cell exhaustion at a lower threshold