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Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide), also known by its developmental code PNB-0408, is a synthetic oligopeptide developed by researchers at Washington State University as a metabolically stable derivative of angiotensin IV

DSIP also has GABAergic activity but appears to modulate sleep architecture rather than simply sedating

Preclinical models examining cellular adaptation and response to experimentally induced stress or injury

Helps manage depression: Dihexas neurotrophic activity extends to mood-regulating circuits and neuroplasticity pathways associated with depression

10.1002/aja.1001270402 187 PfeifferT.PollS.BancelinS.AngibaudJ.Krishna InavalliV