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developed an Fe(III)-shikonin supramolecular nanomedicine (FSSN) using metal-polyphenol coordination of Fe(III) and shikonin, demonstrating improved water solubility and reduced cytotoxicity in normal cells and induced both ferroptosis and necroptosis (Feng et al., 2022)

Recently, it has been demonstrated that a combination of azathioprine with BSO is useful for localized treatment of human hepatocellular carcinoma [62]

Inositol occurs naturally in several forms that the body can produce itself

However, whether excess hemin exposure from the hemolysis in SCD will affect CBS expression and the generation of GSH in oxidative and ferroptosis stress response has not been investigated

The study highlights the necessity for enhanced compliance with resilience standards, a more holistic and systemic planning approach, and greater consideration of socio-economic factors