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They also observed that GHK can easily obtain copper 2+ bound to the high affinity copper transport site on plasma albumin (albumin's binding constant of log 10 = 16.2 versus GHK's binding constant of log 10 = 16.44)

These findings reveal the critical role of SIRT1-mediated activation of autophagy and regulation of mitochondrial homeostasis in ameliorating MAFLD (Figure 1)