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MOTS-c enhances insulin sensitivity, promotes glucose metabolism, and aids in the prevention of metabolic dysfunction, such as insulin resistance and obesity

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Studies have shown that the mRNA, protein content, and activity levels of antioxidant enzymes such as GPX and superoxide dismutase are downregulated in PKD, resulting in an exacerbation of lipid peroxidation reactions, implicating oxidative stress in the growth of PKD cysts

One tier of the cellular protective system against ROS constitutes the family of selenium-dependent glutathione peroxidases (GPx)

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