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Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Yandomized, double-blind, placebo-controlled study

10.1038/nrdp.2015.18 193 TroyanoN.NogalM

For example, when Pharm-IF, a pharmacophore-based interaction fingerprint, was used as input to several ML algorithms for ranking small molecule docking poses, the SVM-based model outperformed other algorithms and docking scores in terms of enrichment rates [183]

This is mainly due to high costs and ethical standards of animal studies and the benefits of in vitro models providing a microenvironment that advances studies of cellular processes on a molecular level [9,10]

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