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A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

No strong evidence indicates its a direct cause of the disease

We have now extended these regulators to include DENND4A and DENND4C, TBC1D13, and a TBC1D1/TBC1D4 heterodimer, and in so doing, established mechanistic links between Retromer and the switching of RAB10 and RAB35

Image resource: royalsociety.org Recognition and cleavage of the specific peptide sequence in the linker utilize the main protease found in the lysosomes of tumor cells through a protease sensitivity strategy