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30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown

Glutathione plays a crucial role in Phase II liver detoxification, which is the pathway the body uses to process and eliminate excess hormones, including estrogen