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2.4.1 Glial changes in ageing Activation of microglial cells is one of the main features associated with CNS senescence, with changes in morphology, functionality, and molecular expression levels

As classical oxidative stress footprints, they correlate with CVD severity

LEACH, C.L., HATOUM, N.S., RATAJCZAK, H.V., & GERHART, J.M

The tracing of the mode of action and determination of an effective dosage are also important and have a major impact on their potential (Jahangiri and Esteban, 2018)