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J Cancer Res Clin Oncol 134(1):6773 Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

It goes beyond to accumulate vital metabolic intermediates, instrumental in guiding T cell differentiation pathways

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Such a peroxide tone is a crucial factor in the regulation of the metabolism of arachidonic acid in toto