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2.2 Inclusion and exclusion criteria 2.2.1 Inclusion criteria Subjects/Disease: Rheumatoid arthritis (RA), including both clinical studies (RA patients) and animal model studies (e.g., collagen-induced arthritis [CIA] and adjuvant-induced arthritis [AIA])

First of all, the study population was mainly from Iran, and the number of participants was small, so it needs to be further verified by increasing the sample size in future studies

Glutamine is needed to produce the neurotransmitter called glutamate

A fifth criterion has just been established by the International RLS Study Group in 2012 that includes ruling out mimics of RLS (leg cramps, arthritis, neuropathies, claudication, positional discomfort, and so forth) that might confound the diagnosis