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For example, in a preclinical study, curcumin was found to reduce levels of heat shock protein 27 (HSP27) and P-glycoprotein (P-gp), causing an increase in the sensitivity of colorectal cancer cells to the chemotherapeutic drug 5-fluorouracil (5-FU), which led to enhanced cell death in 5-FU-resistant HCT-8 cancer cells (He et al

Animals should be allowed to explore the apparatus for about 10 min, with white noise played to eliminate distracting sounds

Therefore, we failed to obtain the optimal cut-offs of serum GPX-3 concentration for all-cause mortality, ESKD, CVA, or ACS in this study (Supplementary Figure S1)

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