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When activated, the mast cells in the skin release mediators (histamines, tryptase, TNF-alpha, CXCL9, etc.) that cause inflammation, flushing, itching, or burning.[ref] Related article: Rosacea, underlying causes, genetic susceptibility Dermatographism and mast cell activation syndrome: In a survey of mast cell activation syndrome, dermatographism was found in 89% of the patients.[ref] Dermatographism is when you get welts or raised red lines when you scratch your skin lightly

Prostate 73, 1090 (2013), Application(s): Measurement of autophagic flux in prostate cancer cells, Abstract Suppression of autophagy enhanced growth inhibition and apoptosis of interferon- in human glioma cells: Y

These findings show that elevation of pre-rRNA synthesis confers a fitness advantage early in life but accelerates health decline with age, while its restriction limits early life fitness transiently and eventually prolongs both lifespan and healthspan