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Prior to the reaction between the acetyl-AMP and CoA, the acetyl-AMP-bound enzyme undergoes a conformational change in which the CTD rotates and leads to the TE conformation

Excess extracellular glutamate triggers mechanisms involving astrocyte-mediated inflammation, including the release of Ca 2+ -dependent glutamate from astrocytes, the appearance of excitotoxicity, the formation of reactive oxygen species (ROS), and cell damage