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Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Dou Y, Lee A, Zhu L, Morton J, & Ladiges W

Symptoms include itching, rash, or breathing issues

Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose

As with anything you put into your body, you may experience some unwanted side effects