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Deamidation of H1N76/77 catalyzed by CTPS1 is prerequisite for a sequential binding of histone acetyltransferase p300 to the reaction site of H1K75

SHH, sonic hedgehog

Initial lumbar T-score (premedication) of 3.2 improved at drug holiday initiation and currently remained so: DXA based lumbar L1L4 BMD = 0.876 g/cm 2 , T-score = 2.5, Z-score = 0.6, total hip BMD = 0.732 g/cm 2 , T-score = 2.2, Z-score = 0.5