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From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Mac Giollabhui et al., 2025), while epidemiological data show that individuals with inflammatory autoimmune diseases like psoriasis have increased risks of experiencing developing anxiety disorders (Lee et al., 2025)

Pro Tip: Track your washout start date and do not begin a new cycle until the minimum threshold has passed

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Cell Metab 31(2):339350 Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M (2019) Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

Most ALA supplements use a racemic mixture, which combines both R- and S-ALA in a 50:50 ratio