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LYMErix, the only FDA-approved LD vaccine for humans, and VLA15, which is currently in clinical trials, both provide protection against Bb by eliciting anti-OspA antibodies

Its actions span telomere preservation (by protecting guanine-rich telomeric DNA from oxidative attack and upregulating SIRT1/SIRT6), mitochondrial quality control (restoring mitophagic flux via PINK1/Parkin pathways), suppression of the pro-inflammatory Senescence-Associated Secretory Phenotype (SASP) via NF-kB inhibition, and modulation of the mTORC1-S6K1 nutrient-sensing axis

Aesculetin (6,7-Dihydroxycoumarin) Exhibits Potent and Selective Antitumor Activity in Human Acute Myeloid Leukemia Cells (THP-1) via Induction of Mitochondrial Mediated Apoptosis and Cancer Cell Migration Inhibition

So, lutein may be a naturally occurring substance that supports bone turnover and is good for human bone health [87]

Post-translational modification and regulation of actin