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More importantly, Nrf2 gene knockout inhibited the antifibrotic effect of AS-IV by downregulating the p-Smad3L/PAI-1 pathway and upregulating the p-Smad3C/p21 pathway (Yang, 2022)

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Anyone interested in the regulatory outcome should monitor the FDA's formal rulemaking process, which must follow the advisory committee recommendation before any change takes legal effect

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