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RA-FLSs exhibit uncontrolled growth and reduced inhibition, resembling transformed cel exhibit a number of characteristics of oncogenic transformation, including enhanced proliferation, resistance to contact inhibition, and escape from apoptosis

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Interestingly, these findings stand in contrast to the work reviewed above, which have consistently found elevated levels of Glu in response to stress and higher levels of Glu contributing to neurotoxicity (Miller et al., 2009

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