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4A, B, SP upregulated the expression of SOD2, HO-1, NRF2, GPX1, and GPX4, while it downregulated the KEAP1 dose-dependently in macrophages

Its internal support that reflects externally over time

Below, we summarize four major categories of polyphenolsflavonoids, phenolic acids, stilbenes, and lignanshighlighting representative compounds and their potential roles in PD prevention or therapy

This relationship is broken by oxidative or electrophilic stressors, which allows Nrf2 to nuclear translocate and attach to antioxidant response molecules (AREs)

Glutathione peroxidase 1 protects against peroxynitrite-induced spiral ganglion neuron damage through attenuating NF-B pathway activation