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3.5 GHK-Cu regulated the SIRT1/STAT3 pathway SIRT1, which is closely associated with cellular metabolism and stress responses, also interacts with the STAT3 pathway (Figures 6AD, DSS-induced mice exhibited significantly increased SIRT1 expression and decreased p-STAT3 expression compared to the Control group

The aorta was fixed in 4% fixative for 3 h, followed by thorough removal of surrounding tissues

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Studies also reveal that doxorubicin enhances the expression of SASP, thereby inducing inflammatory states in p16-3MR cells [60]

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