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600 Similarly, in a controlled clinical trial in which 66 healthy male adults received an aronia extract containing 116 mg of polyphenols, a whole fruit powder, or a placebo daily for 12 weeks, those receiving aronia had improvement in a measure of vascular function and potentially beneficial modifications of the gut microbiota

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In this context, the intranasal route has emerged as a promising solution for delivering treatments directly from the nose to the brain through the olfactory and trigeminal nerve pathways and thus, bypassing the BBB