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If it senses excessively high levels of IGF-1, it can signal the hypothalamus to stop producing GHRH and the pituitary to stop responding to it

Regulation of Nrf2 As previously mentioned, in addition to Nrf2 negative regulators such as Keap1 and GSK3, BTB domain and CNC homolog 1 ( BACH1 ), a heme-binding transcriptional repressor of Nrf2-regulated genes (Dhakshinamoorthy et al