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In contrast to the above, the dysregulation of mTOR signaling triggers the abnormal metabolism of protein, causative of tumor cell persistence and drug challenge, as demonstrated in research investigating the effects of mTOR inhibitors in several tumor models, including renal adenocarcinoma (96)

Model I (single-phase model), as shown in Fig

doi: 10.1038/nature01000 18 KorczE.VargaL

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Superoxide dismutase (SOD) assay The PC-12 cells were seeded onto a 6-well plate at a density of 5 10 5 cells per well and incubated for 24 h at 37 2 C in a 5% CO 2 -humidified incubator