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In rabbits, omeprazole in a dose range of 6.9 to 69.1 mg/kg/day (about 3.4 to 34 times an oral human dose of 40 mg on a body surface area basis) administered during organogenesis produced dose-related increases in embryo-lethality, fetal resorptions, and pregnancy disruptions

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Byndloss MX, Olsan EE, Rivera-Chvez F, Tiffany CR, Cevallos SA, Lokken KL, et al

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Upon internalization, biological processing of a suitably designed linker would release the nuclear hormone and allow activation of its intracellular receptor