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Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel platinum (II) and (IV) ammine/amine complexes

Dickerson F, Adamos M, Katsafanas E, Khushalani S, Origoni A, Savage C, et al

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10.1002/mds.10486 76 FoxJ

Given the resistance of EGFR-altered tumors to conventional EGFR inhibitors, ongoing research into combination therapies and novel targeted approaches remains critical for improving treatment efficacy in EGFR-mutant GBM