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All three series have shown varying degrees of efficacy in specific tissues, such as the lungs, brain, and cardiovascular system (Day, 2004)

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Metastatic or primary lung tumours were shown to rely on enhanced expression of NFS1 to maintain the supply of FeS clusters as co-factors of multiple essential proteins and enzymes in the cell that are exposed to (damaging) high oxygen concentrations

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Intravenous NR or NMN administration in mice results in rapid conversion into circulating NAM and NAD + boosting in liver, kidney, skeletal muscle, while NAD + in these organs after oral administration increases to a lower magnitude 39,69