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When you stack MOTS-c 5-Amino-1MQ, the most effective approach is staggered introduction: establish baseline metabolic parameters (fasting glucose, insulin sensitivity, body composition), introduce MOTS-c alone for 1014 days while monitoring those parameters, then add 5-Amino-1MQ and observe whether the combination produces additive or synergistic effects

10.1016/j.etap.2020.103395 Environ Toxicol Pharmacol