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Traumatic brain injury For decades, preclinical and small clinical studies have investigated the effect of citicoline when provided intravenously, intramuscularly, or orally in the management of traumatic brain injury (TBI)

Specifically, increased expression of AMPA receptors in hypoxic white matter sensitizes microglia to glutamate, leading to a regulatory response that reduces protective IGF-1 release, while increasing the release of inflammatory mediators (Sivakumar et al., 2010)

While glutathione is considered safe, some individuals may experience side effects

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Ermiao San (EMS) and berberine inhibit glycolysis via the HIF-1/GLUT1 axis, thereby reducing lactate accumulation