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b , c , Quantification of extracellular and intracellular ROS levels in WT and XKR8 KO neutrophils treated with PMA (100 nM), measured using isoluminol ( b ) and DHR123 assay ( c ), respectively ( n = 3)

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doi: 10.1002/acr.20577 108 LangleyRGEllisCN

The precise mechanism underlying ferroptosis is still unknown, but it is known that altered iron metabolism, glutathione (GSH) depletion, GPX4 inactivation, and increased PUFA peroxidation by ROS play key roles in its onset and progression [80, 81]