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Continuum 24 , 11081136 (2018)

[18] In this study, the dosage was 500-1000 mg per day for 4 days, then two injections every week for a month, and then one injection every two months as a maintenance dose

Research on apoptotic signaling pathways of recurrent spontaneous abortion caused by dysfunction of trophoblast infiltration

sometimes used for chronic pain, migraine prevention Nortriptyline (Pamelor) Moderate weight gain, less than amitriptyline Still has metabolic risks Clinical use: Sometimes used for depression when SSRIs fail, neuropathic pain Imipramine (Tofranil) Moderate weight gain Associated with metabolic syndrome in longitudinal studies Clinical use: Occasionally for treatment-resistant depression, bedwetting in children Doxepin (Sinequan) Significant weight gain Very sedating Clinical use: Sometimes used for insomnia at very low doses (Silenor) Clomipramine (Anafranil) Moderate to significant weight gain Clinical use: OCD (FDA-approved), sometimes treatment-resistant depression Overall TCA assessment: TCAs as a class carry the highest metabolic risk

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