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Adjustments are necessary for patients with liver impairment or other medical conditions affecting drug metabolism

TSN reduces the phosphorylation and nuclear translocation of STAT3, a critical driver of tumor growth and invasion, by increasing SOCS3 expression, a negative regulator of the JAK2/STAT3 signaling pathway

However, due to receptor desensitization, the chronic use of ACT-389949 might not be possible and new molecules with better pharmacologic characteristics are of interest (Stalder et al., 2017)

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