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Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium

Cys is also a major GSH precursor that affects intracellular GSH levels [35]

10.1001/jamaneurol.2021.4893 109 WooM

Rickettsia have highly reduced genomes with degraded biosynthetic pathways, including the loss of enzymes required for glycolysis, as well as biosynthesis of fatty acids, isoprenoids, vitamins, cofactors and amino acids, and the abundant low molecular weight thiol glutathione (GSH) 5,10,12

Furthermore, in a model of stroke, niacin treatment activates a population of Hcar2-expressing neuroprotective macrophages, which infiltrate into the ischemic brain and ameliorate neuropathology [83]