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Patients with neurological symptoms require urgent same-day treatment initiation to prevent irreversible nerve damage

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Metformin decreases IF, bile acid metabolism for ileal reabsorption, binding of vitamin B12 and IF in the small intestine, decreases cubulin-B12-IF complex binding to amnionless complex, and increases vitamin B12 accumulation in the liver.[2] PPIs decrease H secretion to form hydrochloric acid in the stomach