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In these more intricate scenarios, ML algorithms have demonstrated substantial advantages over rule-based approaches

Indeed, compounds such as 5-aza-cytidine and RG108, which are designed to target DNA methylation, are currently being investigated for their potential efficacy in neurodegenerative diseases, such as PD (201)

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Finally, brain trauma clinically is often severe enough to generate blood-clots, cellular debris and exudates, each exacerbating local pathophysiology and preventing local drug access

Change is difficult, disruptive, and full of uncertainty, but the faster and smarter we act individually and collectively, the more we can prevent and lessen the suffering