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Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice

It is a vital enzyme in the Thymidylate Cycle, which recycles folate after its been used to generate thymidine

We confirmed that GCLC-KO mice have significantly reduced GCLC and glutathione levels, and an elevated ratio of oxidized to total glutathione in their brains (Fig

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Thus, mTORC2 acts as a negative regulator of autophagy through the AKT/FOXO3 signaling axis in skeletal muscle