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25 More recent studies have also linked vitamin D deficiency to sickle cell disease, aromatase inhibitorinduced arthralgia, headache, PHN, pain in patients taking high doses of opioids, and various types of musculoskeletal and orthopedic pain

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The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

Funda DP, Fundova P, Hansen AK, Buschard K (2014) Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice

[DOI] [PubMed] [Google Scholar] 43.Seiwerth S., Sikiric P., Grabarevic Z., Zoricic I., Hanzevacki M., Ljubanovic D., Coric V., Konjevoda P., Petek M., Rucman R., et al